Anyone can do it in ME2 and in ME1 as well (you just have to jump out of the Mako).
Guide to Beat Thresher Maw
- Step 1: Go to a Planet/Moon with Thresher Maws (e.g. Xawin – Strenuus System – Horse Head Nebula).
- Step 2: Weaken it with the Mako until the Life Bar is basically empty.
- Step 3: Hit it a few times with a good Sniper and dodge some acid. That’s it.
- Just swerv around the acid and use the thrusters 100% of the time whenever possible.