This is fast and dirty and leads to you not losing for any reason.
Guide to Basics
Intro, Middle, End
Start the Game, skip the Intro. Put one guy on engines (increased fuel efficiency) and the other on drills (more stuff).
Go to a blue star. These are gas stars. Always use 10 on your probe. Gas up.
Now go to a red star. These are rock stars. Always use 10 on your drill. Save everything you can.
Now go to a yellow star. These are earth stars, find an earth planet and get some air.
That’s your game loop. Always keep a stack of iron in your ship for repairs (but honestly save everything you can), and never ever run out of gas or air. It’s easy, just make sure to hit the stars in that order more or less. You basically cannot die.
Now focus on blueprints, blueprints, blueprints. Personally I save all my stuff until I find the bird ship, but it doesnt really matter because resources are infinite. When you get a new ship, spend some of your elements to build the best engine blue prints. Here you want the improved drill (I guess) and definitely whatever makes your boat faster and better. As far as crew modules, you can toss everything except the med-bay and the best bunks you can afford to build. Every spare inch of your ship should otherwise be for cargo, in the beginning.
When you go to oxygen planets, make sure to hit up villages (or civilized worlds wherever you find them) and trade all your worthless items and cheaper elements for more blueprints and rarer elements. Get your crew increased asap, with one minimum from each of the three fields.
Eventually (not really long, actually) you should be flying around with like two stacks of iron, a stack of helium, a stack of oxygen (I only get this last) and whatever else you are collecting in order to quest/build. Slowly replace your storage with the best ship modules.
Congratulations, you are now invincible. Even if you make some dumb mistake, you have all the materials needed to not die. Nothing can kill you but you and the unending, repetitive nature of oceans of space, which may cause death by boredom.