Shadows Over Loathing – Chemistry Guide

For those without a brain who chose to take chemistry.

Guide to Chemistry

All credit goes to Kenny!

What You Need and Only What You Need to Continue

Chemistry in the game is a real pain. You gotta mix stuff up old-school to make useful things.

This guide’s here to help you beat chemistry class and show you what you can make with that machine (the name slipped my mind). I’ll tell you what you need to pass and how to use it.

  • Step 1: Make Options 2 + 1 + 1 + 2 to make a Vellum Softener Juice.
  • Step 2: Use Vellum Softener on Book.
  • Step 3: Read the book.
  • Step 4: Talk to the Professor about the missing Ingredient.
  • Step 5: Go to The Hilbert House and find the Arsenic.
  • Step 6: Make Options 3132 to make Bronze Revivifying Juice.
  • Step 7: In the room outside the main chemistry room use the juice on the statue.
  • Step 8: With new companion use machine (or book I can’t Remember) back in the main Chemistry room.
  • Step 9: Talk to the Professor again.
  • Step 10: Go to Ocean City.
  • Step 11: Go to Soda House.
  • Step 12: Get the Lithium (I used magic).
  • Step 13: Make Options 4 + 1 + 2 + 3 to make Chrome Polishing Juice.
  • Step 14: Profit.

Advanced Chemistry (For Lazy Hobos)

If you’re looking for a cheat sheet for the chemistry board, you’re in the right place. It was a pain to make, so enjoy, I guess?

To whip up a Chemical Mixture Juice, use the first 2 numbers for the material and the last 2 for its effects.


  • 11xx = Bologna
  • 12xx = Umbraline
  • 13xx = Chalk
  • 14xx = Barnacle
  • 21xx = Vellum
  • 22xx = Asbestos
  • 23xx = Rubber
  • 24xx = Corduroy
  • 31xx = Bronze
  • 32xx = Glass
  • 33xx = Smoke
  • 34xx = Sandwich
  • 41xx = Chrome
  • 42xx = Gold
  • 43xx = Leather
  • 44xx = Hair

What It Does

  • xx11 = Bleach
  • xx12 = Softener
  • xx13 = Deodorizing
  • xx14 = Loosening
  • xx21 = Straightening
  • xx22 = Purifying
  • xx23 = Polishing
  • xx24 = Bending
  • xx31 = Strengthening
  • xx32 = Revivifying
  • xx33 = Removing
  • xx34 = Annihilating
  • xx41 = Insulting
  • xx42 = Doubling
  • xx43 = Thickening
  • xx44 = Dissolving

Using Chemicals to Beat The Game

Ok after some testing it seems that you can beat the game with these chemicals if you happen to have umbraline annihilator while having fixed the professor’s (companion) sense of smell. This is options 1 + 2 + 3 + 4.

Egor Opleuha
About Egor Opleuha 7714 Articles
Egor Opleuha, also known as Juzzzie, is the Editor-in-Chief of Gameplay Tips. He is a writer with more than 12 years of experience in writing and editing online content. His favorite game was and still is the third part of the legendary Heroes of Might and Magic saga. He prefers to spend all his free time playing retro games and new indie games.


  1. Getting the lithium just looks like a small stat test since Jazz Agents only needed 6 moxie to crack the vault

  2. I’d been tearing my hair out trying to figure out if there was something I could make here related to Lamba Iota Theta because I’d misremembered seeing stone as a material option. Thanks much for your sacrifice of time and sanity to prove me wrong.

    Shame we can’t use that Sandwich Doubling juice, though.

    • The Soda House location is given to you after you learn about the lithium ingredient and you talk to the Chem Professor.

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